|Les articles de Marion Vittecoq||https://tourduvalat.centredoc.fr/rss.php?id=6|
Les articles de Marion Vittecoq
de Antonio A. Vázquez, Mercedes de Vargas, Annia Alba, Jorge Sánchez, Pilar Alda, Emeline Sabourin, Marion Vittecoq, Pedro M. Alarcón-Elbal, Jean-Pierre Pointier, Sylvie Hurtrez-Boussès
In Veterinary Parasitology, 275 (November, 2019), 108955
En ligne : www.sciencedirect.com[...]
Fasciolosis is an important food-borne parasitic disease affecting over two million people worldwide with economic losses related to cattle production of up to US$ 3 billion annually. Despite the long known presence of Fasciola hepatica in the Caribbean islands its transmission is not well known. This study reviews historical and recent data on fasciolosis in the West Indies, revealing for the first time the outcomes of sympatric and allopatric fluke/snail interactions in the area by exploring the susceptibility of four lymnaeid species after exposure to F. hepatica isolates from Cuba, the Dominican Republic and France. Overall, Galba cubensis showed a mean prevalence of 71.8% and appears to be the most suitable intermediate host species irrespective of the isolate used. Sympatric combinations (snail and parasite from the same country) were generally more compatible (higher susceptibility, parasite intensity and snail survival post-exposure) and only the allopatric interaction of French G. truncatula/Cuban F. hepatica attained 100% prevalence and mean intensity over 33 rediae/snail. However, certain Dominican populations of Pseudosuccinea columella showed high parasite intensities (>30 rediae/snail) when infected with Cuban flukes, highlighting the potential risks of biological introductions. Overall, high compatibility in most sympatric combinations compared to low or moderate compatibility in allopatric ones, suggests the existence of local adaptation from a long sustained interaction that has led to high rates of transmission. Interestingly, attempts to infect G. schirazensis with sympatric and allopatric flukes failed and coupled with the lowest survival rates which supposes a low risk of fasciolosis transmission in areas where this is the only snail species. Although there are significant gaps in the actual status of fasciolosis transmission from several islands in the West Indies these results show a permanent risk. We conclude that fasciolosis transmission is high in areas where the local snail, G. cubensis, occurs, and will be even higher in the presence of the invasive P. columella.
de Amalia Rataud, Marlene Dupraz, Céline Toty, Thomas Blanchon, Marion Vittecoq, Remi Choquet, Karen D. McCoy
In Zenodon, reviewed and recommended by Peer Community In Ecology, 10.5281/zenodo.2573075 (March, 2019), 18
En ligne : zenodo.org[...]
Functional dispersal (between-site movement, with or without subsequent reproduction) is a key trait acting on the ecological and evolutionary trajectories of a species, with potential cascading effects on other members of the local community. It is often difficult to quantify, and particularly so for small organisms such as parasites. Understanding this life history trait can help us identify the drivers of population dynamics and, in the case of vectors, the circulation of associated infectious agents. In the present study, functional dispersal of the soft tick Ornithodoros maritimus was studied at small scale, within a colony of yellow-legged-gulls (Larus michahellis). Previous work showed a random distribution of infectious agents in this tick at the within-colony scale, suggesting frequent tick movement among nests. This observation contrasts with the presumed strong endophilic nature described for this tick group. By combining an experimental field study, where both nest success and tick origin were manipulated, with Capture-Mark-Recapture modeling, dispersal rates between nests were estimated taking into account both tick capture probability and survival, and considering an effect of tick sex. As expected, tick survival probability was higher in successful nests, where hosts were readily available for the blood meal, than in unsuccessful nests, but capture probability was lower. Dispersal was low overall, regardless of nest state or tick sex, and there was no evidence for tick homing behavior; ticks from foreign nests did not disperse more than ticks in their nest of origin. These results confirm the strong endophilic nature of this tick species, highlighting the importance of life cycle plasticity for adjusting to changes in host availability. However, results also raise questions with respect to the previously described within-colony distribution of infectious agents in ticks, suggesting that tick dispersal either occurs over longer temporal scales and/or that transient host movements outside the breeding period result in vector exposure to a diverse range of infectious agents.
de David Grémillet, Marion Vittecoq, Thierry Boulinier
In Les dossiers d'Agropolis International, 24 (Février 2019), p. 37
En ligne : www.agropolis.fr[...]
Visibles de tous, les oiseaux nous renseignent sur l’état de leurs milieux de vie. Ils y sont exposés aux pollutions plastiques et chimiques, aux agents pathogènes, aux conséquences des changements climatiques et à la surexploitation des ressources naturelles. Bioindicateurs avérés, les oiseaux marins présentent des réponses qualitatives et/ou quantitatives aux changements globaux et émergent comme d’excellentes sentinelles environnementales
Fasciola hepatica-Pseudosuccinea columella interaction: effect of increasing parasite doses, successive exposures and geographical origin on the infection outcome of susceptible and naturally-resistant snails from Cuba
de Annia Alba, Antonio A. Vázquez, Jorge Sánchez, David Duval, Hilda M. Hernández, Emeline Sabourin, Marion Vittecoq, Sylvie Hurtrez-Boussès, Benjamin Gourbal
In Parasites & Vectors, 11(1) (October 2018)
En ligne : parasitesandvectors.biomedcentral.com[...]
Pseudosuccinea columella is one of the most widespread vectors of Fasciola hepatica, a globally distributed trematode that affects humans, livestock and wildlife. The exclusive occurrence in Cuba of susceptible and naturally-resistant populations to F. hepatica within this snail species, offers a fascinating model for evolutionary biology, health sciences and vector control strategies. In particular, resistance in P. columella is characterized by the encapsulation of the parasite by host’s immune cells and has been experimentally tested using different Cuban F. hepatica isolates with no records of successful infection. Here, we aimed to explore for the first time, the effect of different parasite doses, successive exposures and different parasite origins on the infection outcomes of the two phenotypes of P. columella occurring in Cuba.
de Emeline Sabourin, Pilar Alda, Antonio Vázquez, Sylvie Hurtrez-Boussès, Marion Vittecoq
In Trends in Parasitology, 34(10) (October 2018), 891-903
En ligne : linkinghub.elsevier.com[...]
Fasciolosis is a neglected water- and food-borne disease. There are approximately 17 million human cases annually in the world. In some areas, these numbers may be underestimated.
This disease has an important worldwide distribution due to parasite proliferation in a wide range of freshwater snail species and domestic as well as wild mammals, including humans.
Fasciolosis is also considered to be a major veterinary problem because it is responsible for significant losses of productive capacity in livestock (meat and milk).
The (re)emergence of fasciolosis in certain countries can be explained by the recent evolution of human activities, such as the building of irrigation systems, livestock management, the use of unsafe water, and raw vegetable consumption.
Fasciolosis is a worldwide disease caused by the liver fluke Fasciola spp. This food- and water-borne disease is a major public health and veterinary issue. It is currently (re)emerging in several regions mainly due to the rapid evolution of human activities. This article reviews the current knowledge of the impact of irrigation-system management, livestock management, and human diet and hygiene habits on the emergence of fasciolosis. We also identify the gaps in this knowledge and the possible solutions for limiting these impacts. Integrated control seems to be the most effective solution for controlling fasciolosis, because it enables monitoring, prevention, and rapid action in case of the (re)emergence of the disease.
de Marion Vittecoq
In Espaces naturels, 63 (Juillet 2018), 31
de Beata Ujvari, Marcel Klaassen, Nynke Raven, Tracey Russell, Marion Vittecoq, Rodrigo Hamede, Frederic Thomas, Thomas Madsen
In Proceedings of the Royal Society of London B: Biological Sciences, 285(1875) (March 2018), 1-8
En ligne : rspb.royalsocietypublishing.org[...]
Genetic diversity is essential for adaptive capacities, providing organisms with the potential of successfully responding to intrinsic and extrinsic challenges. Although a clear reciprocal link between genetic diversity and resistance to parasites and pathogens has been established across taxa, the impact of loss of genetic diversity by inbreeding on the emergence and progression of non-communicable diseases, such as cancer, has been overlooked. Here we provide an overview of such associations and show that low genetic diversity and inbreeding associate with an increased risk of cancer in both humans and animals. Cancer being a multifaceted disease, loss of genetic diversity can directly (via accumulation of oncogenic homozygous mutations) and indirectly (via increased susceptibility to oncogenic pathogens) impact abnormal cell emergence and escape of immune surveillance. The observed link between reduced genetic diversity and cancer in wildlife may further imperil the long-term survival of numerous endangered species, highlighting the need to consider the impact of cancer in conservation biology. Finally, the somewhat incongruent data originating from human studies suggest that the association between genetic diversity and cancer development is multifactorial and may be tumour specific. Further studies are therefore crucial in order to elucidate the underpinnings of the interactions between genetic diversity, inbreeding and cancer.
de Marion Vittecoq, Mathieu Giraudeau, Tuul Sepp, David J. Marcogliese, Marcel Klaassen, François Renaud, Beata Ujvari, Frederic Thomas
In Evolutionary Applications, https://doi.org/10.1111/eva.12608 (March 2018)
En ligne : doi.wiley.com[...]
Both field and experimental evolution studies have demonstrated that organisms naturally or artificially exposed to environmental oncogenic factors can, sometimes rapidly, evolve specific adaptations to cope with pollutants and their adverse effects on fitness. Although numerous pollutants are mutagenic and carcinogenic, little attention has been given to exploring the extent to which adaptations displayed by organisms living in oncogenic environments could inspire novel cancer treatments, through mimicking the processes allowing these organisms to prevent or limit malignant progression. Building on a substantial knowledge base from the literature, we here present and discuss this progressive and promising research direction, advocating closer collaboration between the fields of medicine, ecology, and evolution in the war against cancer.
de Frederic Thomas, Fabrice Vavre, Tazzio Tissot, Marion Vittecoq, Mathieu Giraudeau, Florence Bernex, Dorothee Misse, François Renaud, Nynke Raven, Christa Beckmann, et al.
In Trends in Cancer, 4(3) (2018-03-01), 169-172
En ligne : www.cell.com[...]
Age is one of the strongest predictors of cancer and risk of death from cancer. Cancer is therefore generally viewed as a senescence-related malady. However, cancer also exists at subclinical levels in humans and other animals, but its earlier effects on the body are poorly known by comparison. We argue here that cancer is a significant but ignored burden on the body and is likely to be a strong selective force from early during the lifetime of an organism. It is time to adopt this novel view of malignant pathologies to improve our understanding of the ways in which oncogenic phenomena influence the ecology and evolution of animals long before their negative impacts become evident and fatal.
de Marion Vittecoq, Hermann Gauduin, Thibault Oudart, Olivier Bertrand, Benjamin Roche, Matthieu Guillemain, Olivier Boutron
In Science of The Total Environment, 595 (octobre 1, 2017), 787-800
En ligne : www.sciencedirect.com[...]
Wild aquatic birds represent a natural reservoir of avian influenza viruses (AIV) that can be spread to poultry. AIV epizootics were associated with huge economic impacts during the last decades and are still of major concern. Within aquatic bird populations AIV are transmitted either by direct contact or through the ingestion of water that has been contaminated by infected individuals. This second route involving environmental transmission is of utmost importance in AIV dynamics, yet it has received far less attention than direct bird-to-bird contamination. Our objective was to combine a hydrodynamic model with data on mallard abundance and AIV infection rate within the population, so as to characterize virus dissemination within a complex wetland network. We chose the Vaccarès hydrosystem as a wetland model since it represents a large part of the Camargue region, which is a major wintering site for a large diversity of aquatic birds including AIV hosts. We aimed to identify the environmental parameters that drive AIV dynamics within this system and the spatio-temporal pattern of dispersion and persistence of viruses. Our results show that in a complex hydrosystem we can expect a great heterogeneity in AIV risk among wetlands. Our simulations underline how a simple “homogeneous box” approach could in the case of deltaic ecosystems minimize the expected risk by diluting it in the whole system. Moreover, such undermining of the risk perception could affect the predictions relative to risk duration. We present a new approach to identify hotspots of virus concentrations within deltaic areas that could take advantage of the duck count data, AIV surveys and hydrodynamic models that may already be available in several major duck wintering areas comprised of complex hydrosystems, such as the large European deltas. Our method could be of particular interest to optimize surveillance strategies in the current context of highly pathogenic AIV diffusion within wild bird populations. / Les auteurs ont modélisé le devenir des virus des grippes aviaires dans l’hydrosystème Vaccarès selon différents scénarios.Ils ont couplé les données hydrologiques du système avec celles dont nous disposons sur la présence des canards hôtes des virus Influenza A, agents des grippes aviaires, sur leur taux d’infection par ces virus et sur la persistance dans l’eau de ces derniers. Ils ont ensuite étudié comment se répartissaient les virus dans les différentes parties de l’hydrosystème Vaccarès en fonction de leur lieu et de leur date d’arrivée.
Il s’agit d’une première étape dans le développement d’un outil de modélisation des dynamiques des VIA dans l’eau en Camargue qui pourra à terme contribuer à optimiser la surveillance et à guider les prises de décision en cas de crise.
de Marlene Dupraz, Céline Toty, Elodie Devillers, Thomas Blanchon, Eric Elguero, Marion Vittecoq, Sara Moutailler, Karen D. McCoy
In International Journal for Parasitology: Parasites and Wildlife, 6(2) (08/2017), 122-130
En ligne : www.sciencedirect.com[...]
The epidemiology of vector-borne zoonoses depends on the movement of both hosts and vectors, which can differ greatly in intensity across spatial scales. Because of their life history traits and small size, vector dispersal may be frequent, but limited in distance. However, little information is available on vector movement patterns at local spatial scales, and particularly for ticks, transmitting the greatest diversity of recognized infectious agents. To test the degree to which ticks can disperse and disseminate pathogens at local scales, we investigated the temporal dynamics and population structure of the soft tick Ornithodoros maritimus within a colony of its seabird host, the Yellow-legged gull Larus michahellis. Ticks were repeatedly sampled at a series of nests during the host breeding season. In half of the nests, ticks were collected (removal sampling), in the other half, ticks were counted and returned to the nest. A subsample of ticks was screened for known bacteria, viruses and parasites using a high throughput real-time PCR system to examine their distribution within the colony. The results indicate a temporal dynamic in the presence of tick life stages over the season, with the simultaneous appearance of juvenile ticks and hatched chicks, but no among-nest spatial structure in tick abundance. Removal sampling significantly reduced tick numbers, but only from the fourth visit onward. Seven bacterial isolates, one parasite species and one viral isolate were detected but no spatial structure in their presence within the colony was found. These results suggest weak isolation among nests and that tick dispersal is likely frequent enough to quickly recolonize locally-emptied patches and disseminate pathogens across the colony. Vector-mediated movements at local scales may therefore play a key role in pathogen emergence and needs to be considered in conjunction with host movements for predicting pathogen circulation and for establishing effective control strategies.
de Parviez R. Hosseini, James N. Mills, Anne-Hélène Prieur-Richard, Vanessa O. Ezenwa, Xavier Bailly, Annapaola Rizzoli, Gerardo Suzán, Marion Vittecoq, Gabriel E. García-Peña, Peter Daszak, et al.
In Philosophical transactions of the Royal Society : biological sciences, 372(1722) (June 2017), 7
En ligne : rstb.royalsocietypublishing.org[...]
Biodiversity is of critical value to human societies, but recent evidence that biodiversity
may mitigate infectious-disease risk has sparked controversy among researchers. The majority of work on this topic has focused on direct assessments of the relationship between biodiversity and endemic-pathogen prevalence, without disentangling intervening mechanisms; thus study outcomes often differ, fuelling more debate. Here, we suggest two critical changes to the approach researchers take to understanding relationships between infectious disease,
both endemic and emerging, and biodiversity that may help clarify sources of controversy. First, the distinct concepts of hazards versus risks need to be separated to determine how biodiversity and its drivers may act differently on each. This distinction is particularly important since it illustrates that disease emergence drivers in humans could be quite different to the general relationship between biodiversity and transmission of endemic pathogens. Second, the interactive relationship among biodiversity, anthropogenic change and zoonotic disease risk, including both direct and indirect effects, needs to be recognized and accounted for. By carefully disentangling these interactions between humans’ activities and pathogen circulation in wildlife, we suggest that conservation
efforts could mitigate disease risks and hazards in novel ways that complement more typical disease control efforts. / Cet article rappelle la différence entre la présence d’une grande diversité de pathogènes, généralement liée à la diversité des hôtes et le risque pour la santé humaine qui n’y est pas forcément associé. En clair quand on conserve la biodiversité on conserve également la diversité des pathogènes qui jouent un rôle important dans les écosystèmes. Ces pathogènes ne posent problème que si l’homme y est sensible et exposé, ce risque augmentant en général quand nous perturbons les habitats. L’article détaille ces principes en se basant sur de nombreux exemples
de Salim Aberkane, Fabrice Compain, Dominique Decré, Alix Pantel, Marion Vittecoq, Jérôme Solassol, Nicolas Bouzinbi, Hélène Jean-pierre, Sylvain Godreuil
In Journal of Global Antimicrobial Resistance, 9 (06/2017), 138-140
En ligne : linkinghub.elsevier.com[...]
This study emphasises the persistence of multidrug resistance determinants in wild gulls, supporting our hypothesis that wild fauna may represent a zoonotic reservoir that may persist for several years without any known antibiotic selection pressure. Clonal analysis proves interspecies transmission with arising zoonotic risks in highly crowded areas.
de Marion Vittecoq, Chrislène Laurens, Lionel Brazier, Patrick Durand, Eric Elguero, Audrey Arnal, Frederic Thomas, Salim Aberkane, Nicolas Renaud, Franck Prugnolle, et al.
In Ecology and Evolution, 7(4) (February, 2017), 1224-1232
En ligne : onlinelibrary.wiley.com[...]
Acquired carbapenemases currently pose one of the most worrying public health threats related to antimicrobial resistance. A NDM-1-producing Salmonella Corvallis was reported in 2013 in a wild raptor. Further research was needed to understand the role of wild birds in the transmission of bacteria resistant to carbapenems. Our aim was to investigate the presence of carbapenem-resistant Escherichia coli in gulls from southern France. In 2012, we collected 158 cloacal swabs samples from two gull species: yellow-legged gulls (Larus michahellis) that live in close contact with humans and slender-billed gulls (Chroicocephalus genei) that feed at sea. We molecularly compared the carbapenem-resistant bacteria we isolated through culture on selective media with the carbapenem-susceptible strains sampled from both gull species and from stool samples of humans hospitalized in the study area. The genes coding for carbapenemases were tested by multiplex PCR. We isolated 22 carbapenem-resistant E. coli strains from yellow-legged gulls while none were isolated from slender-billed gulls. All carbapenem-resistant isolates were positive for blaVIM-1 gene. VIM-1-producing E. coli were closely related to carbapenem-susceptible strains isolated from the two gull species but also to human strains. Our results are alarming enough to make it urgently necessary to determine the contamination source of the bacteria we identified. More generally, our work highlights the need to develop more bridges between studies focusing on wildlife and humans in order to improve our knowledge of resistant bacteria transmission routes./ : Nos équipes ont étudié les bactéries résistantes aux antibiotiques portées par deux espèces de goélands en Camargue.Elles ont ainsi découvert que les poussins de l’espèce pouvant vivre en ville, le goéland leucophée, peuvent être porteurs de bactéries capables de résister à des antibiotiques utilisés uniquement dans les hôpitaux : les carbapénèmes.
de Marion Vittecoq, Benjamin Roche
In Zones Humides Infos, 92-93 (3ème-4ème trim. 2016), 7
En ligne : www.snpn.com[...]
de Marion Vittecoq, F. Thomas
In Bulletin de la société de pathologie exotique (Septembre 2016), 4 p.
En ligne : www.ncbi.nlm.nih.gov[...]
Toxoplasmosis, caused by Toxoplasma gondii, is one of the most prevalent parasitic diseases; it is estimated to affect a third of the world's human population. Many studies showed that latent toxoplasmosis may cause in some patients significant adverse effects including schizophrenia and bipolar disorders. In addition, two recent studies highlighted a positive correlation between the prevalence of brain tumors and that of T. gondii at national and international scale. These studies are correlative, thus they do not demonstrate a causal link between T. gondii and brain tumors. Yet, they call for further research that could shed light on the possible mechanisms underlying this association. / La toxoplasmose, causée par le protozoaire Toxo-plasma gondii , est une des parasitoses les plus répandues, puisqu ’ on estime qu’elle affecte un tiers de la population humaine mondiale. De nombreuses études tendent à démontrer que l ’ infection peut entraîner des effets néfastes importants tels que favoriser la schizophrénie et les troubles bipolaires. De plus, deux études ont récemment mis en évidence une corrélation positive entre la prévalence des tumeurs malignes du cerveau et celle des infections à T. gondii à l ’ échelle nationale et internationale. Ces études étant corrélatives, elles ne démontrent pas de lien causal et appellent d ’ autres recherches qui pourraient mettre en lumière les éventuels mécanismes qui sous-tendent l’association entre T. gondii et tumeurs cérébrales.
de Marion Vittecoq, Sylvain Godreuil, Franck Prugnolle, Patrick Durand, Lionel Brazier, Nicolas Renaud, Audrey Arnal, Salim Aberkane, Hélène Jean-pierre, Michel Gauthier-Clerc, et al.
In Journal of Applied Ecology, 53(2) (April 2016), 519-529
En ligne : doi.wiley.com[...]
* The spread of antimicrobial resistance is of major concern for human health and leads to growing economic costs. While it is increasingly hypothesized that wildlife could play an important role in antimicrobial-resistant bacteria dynamics, empirical data remain scarce.
* The present work builds on a systematic review of the available data in order to highlight the main information we have and to suggest research pathways that should be followed if we aim to fill the gaps in our current knowledge.
* To achieve this goal, we address four questions: (i) Which resistant bacteria are the most frequently observed in wildlife? (ii) How are resistant bacteria exchanged between wildlife and the other hosts involved? (iii) In which habitats are those resistant bacteria found? (iv) Are resistances associated with certain ecological traits of the host?
* Synthesis and applications. We highlight the strong link existing between the impact of human activities on natural habitats and the carriage of antimicrobial-resistant bacteria by wildlife. Furthermore, we underline that omnivorous, anthropophilic and carnivorous species are at high risk of being carriers and potentially spreaders of antimicrobial-resistant bacteria. Identifying among those groups key sentinel species may be of particular interest to implement ecosystem contamination surveillance. Finally, we discuss possible exchange routes for antimicrobial-resistant bacteria between humans and wildlife. Considering that water is of major importance in those exchanges, a critical way to control antimicrobial resistance spread may be to limit aquatic environment contamination by antimicrobial-resistant bacteria and antibiotics.
de Beata Ujvari, Christa Beckmann, Peter A. Biro, Audrey Arnal, Aurelie Tasiemski, Francois Massol, Michel Salzet, Frederic Mery, Celine Boidin-wichlacz, Dorothee Misse, et al.
In Parasitology, 143(5) (April 2016), 533-541
En ligne : www.journals.cambridge.org[...]
Despite important differences between infectious diseases and cancers, tumour development (neoplasia) can nonetheless be closely compared to infectious disease because of the similarity of their effects on the body. On this basis, we predict that many of the life-history(LH) responses observed in the context of host–parasite interactions should also be relevant in the context of cancer. Parasites are thought to affect LH traits of their hosts because of strong selective pressures like direct and indirect mortality effects favouring, for example, early maturation and reproduction. Cancer can similarly also affect LH traits by imposing direct costs and/or indirectly by triggering plastic adjustments and evolutionary responses. Here, we discuss how and why a LH focus is a potentially productive but under-exploited research direction for cancer research, by focusing our attention on similarities between infectious disease and cancer with respect to their effects on LH traits and their evolution. We raise the possibility that LH adjustments can occur in response to cancer via maternal/paternal effects and that these changes can be heritable to (adaptively) modify the LH traits of their offspring. We conclude that LH adjustments can potentially influence the transgenerational persistence of inherited oncogenic mutations in populations.
de Salim Aberkane, Fabrice Compain, Dominique Decré, Chloé Dupont, Chrislène Laurens, Marion Vittecoq, Alix Pantel, Jérôme Solassol, Christian Carrière, François Renaud, et al.
In Antimicrobial Agents and Chemotherapy, 60(2) (Februar), AAC.01654-15
En ligne : aac.asm.org[...]
The genetic structures involved in the dissemination of blaCMY-2 carried by Proteus mirabilis isolates recovered from different gull species in the South of France were characterized and compared to clinical isolates. blaCMY-2 was identified in P. mirabilis isolates from 27/93 yellow-legged gulls and from 37/65 slender-billed gulls. It was carried by a conjugative SXT/R391-like integrative and conjugative element (ICE) in all avian strains and in 3/7 human strains. Two clinical isolates had the same genetic background as six avian isolates.
de Audrey Arnal, Tazzio Tissot, Beata Ujvari, Leonard Nunney, Eric Solary, Lucie Laplane, François Bonhomme, Marion Vittecoq, Aurelie Tasiemski, François Renaud, et al.
In Evolution, 70(1) (January 2016), 1-6
En ligne : doi.wiley.com[...]
Similar to seemingly maladaptive genes in general, the persistence of inherited cancer-causing mutant alleles in populations remains a challenging question for evolutionary biologists. In addition to traditional explanations such as senescence or antagonistic pleiotropy, here we put forward a new hypothesis to explain the retention of oncogenic mutations. We propose that although natural defenses evolve to prevent neoplasm formation and progression thus increasing organismal fitness, they also conceal the effects of cancer-causing mutant alleles on fitness and concomitantly protect inherited ones from purging by purifying selection. We also argue for the importance of the ecological contexts experienced by individuals and/or species. These contexts determine the locally predominant fitness-reducing risks, and hence can aid the prediction of how natural selection will influence cancer outcome
de François Renaud, Marion Vittecoq
In la revue d’humanité et biodiversité (Octobre 2015), 84
En ligne : lucperino.com[...]
de Audrey Arnal, A. Droit, H. Ducasse, M. Sanchez, T. Lefevre, D. Misse, M. Beredina, Marion Vittecoq, S. Daoust, F. Thomas
de V. O. Ezenwa, A.-H. Prieur-richard, B. Roche, X. Bailly, P. Becquart, G. E. Garcia-pena, P. R. Hosseini, F. Keesing, A. Rizzoli, G. Suzan, et al.
de Suzan G., Garcia-pena G., Castro-avellano I., Rico O., Rubio A., Tolsa M., Roche B., Hosseini P., Rizzoli A., Murray K., et al.
de Marion Vittecoq, B. Roche, J.-M. Cohen, F. Renaud, F. Thomas, Michel Gauthier-Clerc
de Audrey Arnal, E. Gomez-diaz, M. Cerda-cuellar, S. Lecollinet, J. Pearce-duvet, N. Busquets, I. Garcia-bocanegra, N. Pages, Marion Vittecoq
de Audrey Arnal, Marion Vittecoq, J. Pearce-duvet, Michel Gauthier-Clerc, T. Boulinier, E. Jourdain
de Marion Vittecoq, F. Thomas, E. Jourdain, F. Moutou, F. Renaud, Michel Gauthier-Clerc
de Marion Vittecoq, B. Roche, S. P. Daoust, H. Ducasse, D. Misse, J. Abadie, S. Labrut, F. Renaud, Michel Gauthier-Clerc, F. Thomas
de Marion Vittecoq, S. Lecollinet, E. Jourdain, F. Thomas, T. Blanchon, Audrey Arnal, S. Lowenski, Michel Gauthier-Clerc
de Marion Vittecoq, E. Elguero, K.D. Lafferty, B. Roche, J. Brodeur, Michel Gauthier-Clerc, D. Misse, F. Thomas
de Marion Vittecoq, V. Grandhomme, Jocelyn Champagnon, Matthieu Guillemain, B. Crescenzo-chaigne, F. Renaud, F. Thomas, Michel Gauthier-Clerc, S. Van Der Werf
de Marion Vittecoq
[S.l.] : Thèse doctorat: biologie de l'évolution et écologie: Université Montpellier 2, 2012, * 114p
de Marion Vittecoq, F. Thomas, E. Jourdain, F. Moutou, F. Renaud, Michel Gauthier-Clerc
de Marion Vittecoq, V. Grandhomme, G. Simon, S. Herve, T. Blanchon, F. Renaud, F. Thomas, Michel Gauthier-Clerc, S. Van Der Werf
de Marion Vittecoq, M. Ottmann, F. Renaud, F. Thomas, Michel Gauthier-Clerc
de Michel Gauthier-Clerc, V. Grandhomme, C. Lebarbenchon, Marion Vittecoq, Yves Kayser, F. Renaud, F. Thomas, S. Van Der Werf